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I felt extremely jittery, anxious, disoriented, and numbness in the hands and feet on a relatively small dose of Propranolol (20mg three times daily). Significant increases in AUC (27%) and Cmax (58%) and decreases in tmax (23%) of propranolol were noted in this study. There are a number of abnormalities associated with the use of propranolol during pregnancy, but many of these may be attributable to underlying diseases. Beta-blockers (atenolol, bisoprolol, metoprolol, nadolol, pindolol, propranolol, and timolol) reduce the work load on the heart as well as having other effects. It has approximately one fortieth of the beta-adrenergic blocking activity of propranolol {01}, which may become clinically significant in some patients {61} {62}.
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